SrasV1, Main, Exploration, bibRecord, 001998

ACE2 - from the renin-angiotensin system to gut microbiota and malnutrition.

Identifieur interne : 001998 ( Main/Exploration ); précédent : 001997; suivant : 001999

ACE2 - from the renin-angiotensin system to gut microbiota and malnutrition.

Auteurs : Thomas Perlot [Autriche] ; Josef M. Penninger

Source :

Microbes and infection [ 1769-714X ] ; 2013.

RBID : pubmed:23962453

Descripteurs français

KwdFr :
- Facteurs immunologiques (métabolisme), Humains, Immunité innée, Malnutrition, Peptidyl-Dipeptidase A (métabolisme), Récepteurs viraux (métabolisme), Système rénine-angiotensine, Systèmes de transport d'acides aminés neutres (métabolisme), Tube digestif (immunologie), Virus du SRAS (physiologie).
MESH :
- immunologie : Tube digestif.
- métabolisme : Facteurs immunologiques, Peptidyl-Dipeptidase A, Récepteurs viraux, Systèmes de transport d'acides aminés neutres.
- physiologie : Virus du SRAS.
- Humains, Immunité innée, Malnutrition, Système rénine-angiotensine.

English descriptors

KwdEn :
- Amino Acid Transport Systems, Neutral (metabolism), Gastrointestinal Tract (immunology), Humans, Immunity, Innate, Immunologic Factors (metabolism), Malnutrition, Peptidyl-Dipeptidase A (metabolism), Receptors, Virus (metabolism), Renin-Angiotensin System, SARS Virus (physiology).
MESH :
- chemical , metabolism : Amino Acid Transport Systems, Neutral, Immunologic Factors, Peptidyl-Dipeptidase A, Receptors, Virus.
- immunology : Gastrointestinal Tract.
- physiology : SARS Virus.
- Humans, Immunity, Innate, Malnutrition, Renin-Angiotensin System.

Abstract

The renin-angiotensin system (RAS) is a complex network that regulates blood pressure, electrolyte and fluid homeostasis, as well as the function of several organs. Angiotensin-converting enzyme 2 (ACE2) was identified as an enzyme that negatively regulates the RAS by converting Ang II, the main bioactive molecule of the RAS, to Ang 1-7. Thus, ACE2 counteracts the role of angiotensin-converting enzyme (ACE) which generates Ang II from Ang I. ACE and ACE2 have been implicated in several pathologies such as cardiovascular and renal disease or acute lung injury. In addition, ACE2 has functions independent of the RAS: ACE2 is the receptor for the SARS coronavirus and ACE2 is essential for expression of neutral amino acid transporters in the gut. In this context, ACE2 modulates innate immunity and influences the composition of the gut microbiota, which can explain diarrhea and intestinal inflammation observed in Hartnup disorder, Pellagra, or under conditions of severe malnutrition. Here we review and discuss the diverse functions of ACE2 and its relevance to human pathologies.

DOI: 10.1016/j.micinf.2013.08.003
PubMed: 23962453

Affiliations:

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<term>Systèmes de transport d'acides aminés neutres (métabolisme)</term>
<term>Tube digestif (immunologie)</term>
<term>Virus du SRAS (physiologie)</term>
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<term>Receptors, Virus</term>
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<term>Systèmes de transport d'acides aminés neutres</term>
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<front><div type="abstract" xml:lang="en">The renin-angiotensin system (RAS) is a complex network that regulates blood pressure, electrolyte and fluid homeostasis, as well as the function of several organs. Angiotensin-converting enzyme 2 (ACE2) was identified as an enzyme that negatively regulates the RAS by converting Ang II, the main bioactive molecule of the RAS, to Ang 1-7. Thus, ACE2 counteracts the role of angiotensin-converting enzyme (ACE) which generates Ang II from Ang I. ACE and ACE2 have been implicated in several pathologies such as cardiovascular and renal disease or acute lung injury. In addition, ACE2 has functions independent of the RAS: ACE2 is the receptor for the SARS coronavirus and ACE2 is essential for expression of neutral amino acid transporters in the gut. In this context, ACE2 modulates innate immunity and influences the composition of the gut microbiota, which can explain diarrhea and intestinal inflammation observed in Hartnup disorder, Pellagra, or under conditions of severe malnutrition. Here we review and discuss the diverse functions of ACE2 and its relevance to human pathologies. </div>
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Serveur d'exploration SRAS

ACE2 - from the renin-angiotensin system to gut microbiota and malnutrition.

ACE2 - from the renin-angiotensin system to gut microbiota and malnutrition.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration SRAS
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.